Adenosine-containing molecules amplify glucose signaling and enhance txnip expression.

@article{Yu2009AdenosinecontainingMA,
  title={Adenosine-containing molecules amplify glucose signaling and enhance txnip expression.},
  author={Fa-xing Yu and Shuang-Ru Goh and Ru-ping Dai and Yan Luo},
  journal={Molecular endocrinology},
  year={2009},
  volume={23 6},
  pages={932-42}
}
Eukaryotic cells sense extracellular glucose concentrations via diverse mechanisms to regulate the expression of genes involved in metabolic control. One such example is the tight correlation between the expression of thioredoxin-interacting protein (Txnip) and extracellular glucose levels. In this report, we show that the transcription of the Txnip gene is induced by adenosine-containing molecules, of which an intact adenosine moiety is necessary and sufficient. Txnip promoter contains a… CONTINUE READING

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