Adenosine as a pro-inflammatory mediator in asthma.

@article{Polosa1989AdenosineAA,
  title={Adenosine as a pro-inflammatory mediator in asthma.},
  author={R. Polosa and S. Holgate and M. Church},
  journal={Pulmonary pharmacology},
  year={1989},
  volume={2 1},
  pages={
          21-6
        }
}
Adenosine, which may be formed by all cells during relative energy or oxygen deficit, may act as an autocoid by modifying the function of other cells in the local environment. In asthmatic, but not normal, subjects, inhalation of adenosine causes a marked bronchoconstriction which may be reduced by the purinoceptor antagonist theophylline, sodium cromoglycate, nedocromil sodium, histamine, H1-antagonists and cyclo-oxygenase inhibitors. Repeated exposure to adenosine induces a state of… Expand
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References

SHOWING 1-10 OF 51 REFERENCES
Relationships between adenosine, cyclic nucleotides, and xanthines in asthma.
An animal model for adenosine-induced bronchoconstriction.
Release of prostaglandin D2 into human airways during acute antigen challenge.
Release of adenosine from rat lung by antigen and compound 48/80.
  • B. Fredholm
  • Chemistry, Medicine
  • Acta physiologica Scandinavica
  • 1981
Relationship between mediator release from human lung mast cells in vitro and in vivo.
Effect of indomethacin on adenosine-induced bronchoconstriction.
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