Adenosine as a pro-inflammatory mediator in asthma.

@article{Polosa1989AdenosineAA,
  title={Adenosine as a pro-inflammatory mediator in asthma.},
  author={R. Polosa and S. Holgate and M. Church},
  journal={Pulmonary pharmacology},
  year={1989},
  volume={2 1},
  pages={
          21-6
        }
}
Adenosine, which may be formed by all cells during relative energy or oxygen deficit, may act as an autocoid by modifying the function of other cells in the local environment. In asthmatic, but not normal, subjects, inhalation of adenosine causes a marked bronchoconstriction which may be reduced by the purinoceptor antagonist theophylline, sodium cromoglycate, nedocromil sodium, histamine, H1-antagonists and cyclo-oxygenase inhibitors. Repeated exposure to adenosine induces a state of… Expand
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