Adenosine as a non-opioid analgesic in the perioperative setting.

  title={Adenosine as a non-opioid analgesic in the perioperative setting.},
  author={Tong J Gan and Ashraf S Habib},
  journal={Anesthesia and analgesia},
  volume={105 2},
Adenosine, a ubiquitous metabolic intermediate in the body, is involved in nearly every aspect of cell function, including neuromodulation and neurotransmission. Adenosine A(1) and A(2) receptors are widely distributed in the brain and spinal cord, and are a novel, non-opiate target for pain management. The potential of adenosine as a non-narcotic analgesic in anesthetized patients has been explored in clinical trials, including double-blind studies versus placebo and remifentanil infusion… CONTINUE READING
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