Adenosine and prostaglandin E2 cooperate in the suppression of immune responses mediated by adaptive regulatory T cells.

@article{Mandapathil2010AdenosineAP,
  title={Adenosine and prostaglandin E2 cooperate in the suppression of immune responses mediated by adaptive regulatory T cells.},
  author={Magis Mandapathil and Miroslaw J Szczepanski and Marta E. Szajnik and Jin Ren and Edwin K Jackson and Jonas T. Johnson and Elieser Gorelik and S. W. Lang and Theresa L Whiteside},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 36},
  pages={27571-80}
}
Adaptive regulatory T cells (Tr1) are induced in the periphery upon encountering cognate antigens. In cancer, their frequency is increased; however, Tr1-mediated suppression mechanisms are not yet defined. Here, we evaluate the simultaneous involvement of ectonucleotidases (CD39/CD73) and cyclooxygenase 2 (COX-2) in Tr1-mediated suppression. Human Tr1 cells were generated from peripheral blood mononuclear cell-derived, sorted CD4(+)CD25(-) T cells and incubated with autologous immature… CONTINUE READING
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