Adenosine and neurotrauma: therapeutic perspectives.

  title={Adenosine and neurotrauma: therapeutic perspectives.},
  author={John W. Phillis and Harry G Goshgarian},
  journal={Neurological research},
  volume={23 2-3},
Cerebral ischemia studies demonstrating that stimulation of adenosine A1 receptors by either endogenously released adenosine or the administration of selective receptor agonists causes significant reductions in the morbidity and mortality associated with focal or global brain ischemias have triggered interest in the potential of purinergic therapies for the treatment of traumatic injuries to the brain and spinal cord. Preliminary findings indicate that activation of A1 adenosine receptors can… CONTINUE READING