Adenosine and kidney function.

@article{Vallon2006AdenosineAK,
  title={Adenosine and kidney function.},
  author={Volker Vallon and Bernd M{\"u}hlbauer and Hartmut Osswald},
  journal={Physiological reviews},
  year={2006},
  volume={86 3},
  pages={
          901-40
        }
}
In this review we outline the unique effects of the autacoid adenosine in the kidney. Adenosine is present in the cytosol of renal cells and in the extracellular space of normoxic kidneys. Extracellular adenosine can derive from cellular adenosine release or extracellular breakdown of ATP, AMP, or cAMP. It is generated at enhanced rates when tubular NaCl reabsorption and thus transport work increase or when hypoxia is induced. Extracellular adenosine acts on adenosine receptor subtypes in the… Expand

Paper Mentions

Interventional Clinical Trial
The purpose of the study is compare the effects of peri-operative administration of aminophylline (non-specific adenosine receptor antagonist) versus saline placebo in the… Expand
ConditionsAcute Kidney Injury
InterventionDrug
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Exogenous adenosine has been shown to affect nearly all aspects of renal function: renal blood flow and its distribution within the kidney, glomerular filtration rate, renin secretion, urine flow,Expand
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TLDR
The ecto-5'-nucleotidase seems to represent the major source of extracellular adenosine in the kidney; that enzyme is present in tubular luminal membranes, in fibroblasts, and in mesangial cells; in tubules the enzyme probably plays a role in the salvage of nucleotides present in the primary urine. Expand
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TLDR
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TLDR
It is suggested that occupation of A1- and A2-receptors inhibits and stimulates renin secretion in vivo, independently of the effects of these adenosine receptor agonists on arterial blood pressure, renal hemodynamics, and tubular Na and K transport. Expand
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