Adenosine and gastrointestinal inflammation

  title={Adenosine and gastrointestinal inflammation},
  author={Sean P Colgan and Blair P Fennimore and Stefan Felix Ehrentraut},
  journal={Journal of Molecular Medicine},
Nucleosides such as adenosine (Ado) influence nearly every aspect of physiology and pathophysiology. Extracellular nucleotides liberated at local sites of inflammation are metabolized through regulated phosphohydrolysis by a series of ecto-nucleotidases including ectonucleoside triphosphate diphosphohydrolase-1 (CD39) and ecto-5′-nucleotidase (CD73), found on the surface of a variety of cell types. Once generated, Ado is made available to bind and activate one of four G protein-coupled Ado… CONTINUE READING


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