Adenosine and bone metabolism.

  title={Adenosine and bone metabolism.},
  author={Ar{\'a}nzazu Mediero and Bruce Cronstein},
  journal={Trends in endocrinology and metabolism: TEM},
  volume={24 6},
Bone is a dynamic organ that undergoes continuous remodeling while maintaining a balance between bone formation and resorption. Osteoblasts, which synthesize and mineralize new bone, and osteoclasts, the cells that resorb bone, act in concert to maintain bone homeostasis. In recent years, there has been increasing appreciation of purinergic regulation of bone metabolism. Adenosine, released locally, mediates its physiologic and pharmacologic actions via interactions with G protein-coupled… CONTINUE READING
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