Adenosine analogues stimulate cyclic AMP-accumulation in cultured neuroblastoma and glioma cells.

@article{Elfman1984AdenosineAS,
  title={Adenosine analogues stimulate cyclic AMP-accumulation in cultured neuroblastoma and glioma cells.},
  author={Lena Elfman and Eva Lindgren and Erik Walum and Bertil B. Fredholm},
  journal={Acta pharmacologica et toxicologica},
  year={1984},
  volume={55 4},
  pages={297-302}
}
The effect of three stable adenosine analogues, L-phenylisopropyl-adenosine (L-PIA), 2-chloroadenosine, and adenosine 5'-ethylcarboxamide (NECA), on cyclic AMP accumulation was studied in five different cell lines derived from the nervous system. In N18-neuroblastoma cells, with cholinergic properties, all three analogues caused an increased accumulation of cyclic AMP with the following relative order of potency: NECA greater than 2-chloroadenosine greater than L-PIA. The half maximal effect of… CONTINUE READING