Adenosine analogs and sleep in rats.

  title={Adenosine analogs and sleep in rats.},
  author={Miodrag G. Radulovacki and R. M. Virus and M Djuricic-Nedelson and Richard D. Green},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={228 2},
The effects of N6-L-(phenylisopropyl)adenosine, cyclohexyladenosine and adenosine-5'-N-ethylcarboxamide on sleep were examined in rats. These effects consist of 1) increased slow-wave sleep2 from 6.6 to 45.7%, in all doses used for cyclohexyladenosine and adenosine-5'-N-ethylcarboxamide and for 0.1 and 0.3 mumol/kg of N6-L-(phenylisopropyl)adenosine and 2) increased values for rapid-eye-movement-sleep, amounting to 56.2 and 51.6% for 0.1 mumol/kg of cyclohexyl-adenosine and 0.3 mumol/kg of N6-L… CONTINUE READING

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