Corpus ID: 24263104

Adenosine analogs and sleep in rats.

  title={Adenosine analogs and sleep in rats.},
  author={M. Radulova{\vc}ki and R. M. Virus and M. Djuricic-Nedelson and R. D. Green},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={228 2},
  • M. Radulovački, R. M. Virus, +1 author R. D. Green
  • Published 1984
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • The effects of N6-L-(phenylisopropyl)adenosine, cyclohexyladenosine and adenosine-5'-N-ethylcarboxamide on sleep were examined in rats. These effects consist of 1) increased slow-wave sleep2 from 6.6 to 45.7%, in all doses used for cyclohexyladenosine and adenosine-5'-N-ethylcarboxamide and for 0.1 and 0.3 mumol/kg of N6-L-(phenylisopropyl)adenosine and 2) increased values for rapid-eye-movement-sleep, amounting to 56.2 and 51.6% for 0.1 mumol/kg of cyclohexyl-adenosine and 0.3 mumol/kg of N6-L… CONTINUE READING
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