Adenosine administration produces an antidepressant-like effect in mice: evidence for the involvement of A1 and A2A receptors.

@article{Kaster2004AdenosineAP,
  title={Adenosine administration produces an antidepressant-like effect in mice: evidence for the involvement of A1 and A2A receptors.},
  author={Manuella Pinto Kaster and Angelo Oscar Rosa and Matheus M Rosso and Eduardo Comeli Goulart and Adair Roberto Soares dos Santos and Ana L{\'u}cia S Rodrigues},
  journal={Neuroscience letters},
  year={2004},
  volume={355 1-2},
  pages={21-4}
}
This study investigated the effect of adenosine in the forced swimming test (FST) and the tail suspension test (TST) in mice, and the contribution of adenosine A1 and A2A receptors to adenosine's antidepressant-like effect. The immobility time in the FST was reduced by adenosine given either by i.p. (5-10 mg/kg) or i.c.v. (0.01-10 microg/site) route. Adenosine (1-10 mg/kg, i.p.) also produced an antidepressant-like effect in the TST. No treatment affected locomotion in an open-field. The anti… CONTINUE READING

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