Adenosine acts as a chemoprotective agent by stimulating G-CSF production: a role for A1 and A3 adenosine receptors.

@article{Fishman2000AdenosineAA,
  title={Adenosine acts as a chemoprotective agent by stimulating G-CSF production: a role for A1 and A3 adenosine receptors.},
  author={Pnina Fishman and Sara Bar-Yehuda and Tamar Farbstein and Faina Barer and Gil Ohana},
  journal={Journal of cellular physiology},
  year={2000},
  volume={183 3},
  pages={393-8}
}
Adenosine, a ubiquitous nucleoside, is released into the extracellular environment from metabolically active or stressed cells. It binds to cells through specific A1, A(2A), A(2B), and A3 G-protein-associated cell-surface receptors, thus acting as a signal-transduction molecule by regulating the levels of adenylyl cyclase and phospholipase C. In this study, we showed that adenosine stimulates the proliferation of murine bone marrow cells in vitro. Pharmacological studies, using antagonists to… CONTINUE READING

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