Adenosine Triphosphate stimulates differentiation and mineralization in human osteoblast-like Saos-2 cells.

In the last years adenosine triphosphate (ATP) and subsequent purinergic system activation through P2 receptors were investigated highlighting their pivotal role in bone tissue biology. In osteoblasts ATP can regulate several activities like cell proliferation, cell death, cell differentiation and matrix mineralization. Since controversial results exist, in… CONTINUE READING