Adenosine A3 receptor deficiency exerts unanticipated protective effects on the pressure-overloaded left ventricle.

Abstract

BACKGROUND Endogenous adenosine can protect the overloaded heart against the development of hypertrophy and heart failure, but the contribution of A(1) receptors (A(1)R) and A(3) receptors (A(3)R) is not known. METHODS AND RESULTS To test the hypothesis that A(1)R and A(3)R can protect the heart against systolic overload, we exposed A(3)R gene-deficient… (More)
DOI: 10.1161/CIRCULATIONAHA.108.788307

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@article{Lu2008AdenosineAR, title={Adenosine A3 receptor deficiency exerts unanticipated protective effects on the pressure-overloaded left ventricle.}, author={Zhongbing Lu and John T. Fassett and Xin Xu and Xinli Hu and Guangshuo Zhu and Joel P. French and Ping Zhang and J{\"{u}rgen B. Schnermann and Robert J. Bache and Yingjie Chen}, journal={Circulation}, year={2008}, volume={118 17}, pages={1713-21} }