Adenosine A2b receptors mediate an increase in interleukin (IL)-6 mRNA and IL-6 protein synthesis in human astroglioma cells.

@article{Fiebich1996AdenosineAR,
  title={Adenosine A2b receptors mediate an increase in interleukin (IL)-6 mRNA and IL-6 protein synthesis in human astroglioma cells.},
  author={Bernd L. Fiebich and Knut Biber and K Gyufko and Melvin Berger and Jan Niklas Bauer and Dietrich van Calker},
  journal={Journal of neurochemistry},
  year={1996},
  volume={66 4},
  pages={1426-31}
}
The cytokine interleukin (IL)-6 has recently been demonstrated to play a role in the pathology of Alzheimer's disease (AD). The mechanisms leading to increased IL-6 levels in brains of AD patients are still unknown. Because in experimental animals ischemia increases both the levels of cytokines and the extracellular concentrations of adenosine in the brain, we hypothesized that these two phenomena may be functionally connected and that adenosine might increase IL-6 gene expression in the brain… CONTINUE READING

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