Adenosine A2a receptor antagonists attenuate striatal adaptations following dopamine depletion.

@article{Peterson2012AdenosineAR,
  title={Adenosine A2a receptor antagonists attenuate striatal adaptations following dopamine depletion.},
  author={Jayms D. Peterson and Joshua A. Goldberg and D. James Surmeier},
  journal={Neurobiology of disease},
  year={2012},
  volume={45 1},
  pages={409-16}
}
The motor symptoms of Parkinson's disease (PD) are widely thought to arise from an imbalance in the activity of the two major striatal efferent pathways following the loss of dopamine (DA) signaling. In striatopallidal, indirect pathway spiny projection neurons (iSPNs), intrinsic excitability rises following the loss of inhibitory D2 receptor signaling. Because these receptors are normally counterbalanced by adenosine A2a adenosine receptors, antagonists of these receptors are being examined as… CONTINUE READING