Adenosine A2A receptors modify motor function in MPTP-treated common marmosets.

@article{Kanda1998AdenosineAR,
  title={Adenosine A2A receptors modify motor function in MPTP-treated common marmosets.},
  author={Takeshi Kanda and Takashi Tashiro and Yoshihisa Kuwana and P Feroz Jenner},
  journal={Neuroreport},
  year={1998},
  volume={9 12},
  pages={2857-60}
}
Both adenosine A1 and A2 receptor populations are located in the striatum and can modify locomotor activity, and they may form a therapeutic target for Parkinson's disease (PD). Administration of the selective adenosine A2A antagonist (E)-1,3-diethyl-8-(3,4-dimethoxystyryl)-7-methyl-3,7-dihydro-1H-pu rine-2,6-dione (KW-6002) to MPTP-treated common marmosets increased locomotor activity. In contrast, administration of the selective A1 receptor antagonist 1,3-dipropyl-8-cyclopentylxantine (DPCPX… CONTINUE READING

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