Adenosine A2A receptors in ventral striatum, hypothalamus and nociceptive circuitry implications for drug addiction, sleep and pain.

@article{Ferr2007AdenosineAR,
  title={Adenosine A2A receptors in ventral striatum, hypothalamus and nociceptive circuitry implications for drug addiction, sleep and pain.},
  author={Sergi Ferr{\'e} and Ivan Diamond and Steven R. Goldberg and Li Yao and Susanna M. o. Hourani and Zhi Li Huang and Yoshihiro Urade and I. Kitchen},
  journal={Progress in neurobiology},
  year={2007},
  volume={83 5},
  pages={332-47}
}
Adenosine A2A receptors localized in the dorsal striatum are considered as a new target for the development of antiparkinsonian drugs. Co-administration of A2A receptor antagonists has shown a significant improvement of the effects of l-DOPA. The present review emphasizes the possible application of A2A receptor antagonists in pathological conditions other than parkinsonism, including drug addiction, sleep disorders and pain. In addition to the dorsal striatum, the ventral striatum (nucleus… CONTINUE READING

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