Adenosine A2A receptor gene (ADORA2A) variants may increase autistic symptoms and anxiety in autism spectrum disorder

@article{Freitag2009AdenosineAR,
  title={Adenosine A2A receptor gene (ADORA2A) variants may increase autistic symptoms and anxiety in autism spectrum disorder},
  author={Christine M. Freitag and Konstantin Agelopoulos and Ellen Huy and Matthias Rothermundt and Petra Krakowitzky and Jobst Meyer and J{\"u}rgen Deckert and Alexander von Gontard and Christa Hohoff},
  journal={European Child & Adolescent Psychiatry},
  year={2009},
  volume={19},
  pages={67-74}
}
Autism spectrum disorders (ASDs) are heterogeneous disorders presenting with increased rates of anxiety. The adenosine A2A receptor gene (ADORA2A) is associated with panic disorder and is located on chromosome 22q11.23. Its gene product, the adenosine A2A receptor, is strongly expressed in the caudate nucleus, which also is involved in ASD. As autistic symptoms are increased in individuals with 22q11.2 deletion syndrome, and large 22q11.2 deletions and duplications have been observed in ASD… CONTINUE READING

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