Adenosine A2A receptor deficiency exacerbates white matter lesions and cognitive deficits induced by chronic cerebral hypoperfusion in mice.

@article{Duan2009AdenosineAR,
  title={Adenosine A2A receptor deficiency exacerbates white matter lesions and cognitive deficits induced by chronic cerebral hypoperfusion in mice.},
  author={W. Duan and Li Gui and Zhujuan Zhou and Yong Liu and Hong Tian and Jiang-fan Chen and Jian Zheng},
  journal={Journal of the neurological sciences},
  year={2009},
  volume={285 1-2},
  pages={39-45}
}
Adenosine A2A receptor inactivation consistently protects against acute ischemic brain injury; however, the role of the A2A receptor in chronic cerebral ischemia is unknown. To elucidate that, chronic cerebral hypoperfusion model was established by permanent stenosis of bilateral common carotid artery in A2A receptor knock-out mice and their wild-type littermates in this study. White matter lesions were observed after stenosis of common carotid arteries in both A2A receptor knock-out mice and… CONTINUE READING