Adenosine A2A receptor antagonists are potential antidepressants: evidence based on pharmacology and A2A receptor knockout mice.

@article{Yacoubi2001AdenosineAR,
  title={Adenosine A2A receptor antagonists are potential antidepressants: evidence based on pharmacology and A2A receptor knockout mice.},
  author={Malika El Yacoubi and Catherine A. Ledent and Marc Parmentier and Rosalia Bertorelli and Ennio Ongini and Jean Costentin and J M Vaugeois},
  journal={British journal of pharmacology},
  year={2001},
  volume={134 1},
  pages={68-77}
}
1. Adenosine, an ubiquitous neuromodulator, and its analogues have been shown to produce 'depressant' effects in animal models believed to be relevant to depressive disorders, while adenosine receptor antagonists have been found to reverse adenosine-mediated 'depressant' effect. 2. We have designed studies to assess whether adenosine A2A receptor antagonists, or genetic inactivation of the receptor would be effective in established screening procedures, such as tail suspension and forced swim… CONTINUE READING