Adenosine A2A receptor agonist ameliorates EAE and correlates with Th1 cytokine‐induced blood brain barrier dysfunction via suppression of MLCK signaling pathway

@inproceedings{Liu2018AdenosineAR,
  title={Adenosine A2A receptor agonist ameliorates EAE and correlates with Th1 cytokine‐induced blood brain barrier dysfunction via suppression of MLCK signaling pathway},
  author={Ying Liu and Marwan Alahiri and Bianca Ulloa and Boxun Xie and Saud Ahmed Sadiq},
  booktitle={Immunity, inflammation and disease},
  year={2018}
}
INTRODUCTION Multiple sclerosis (MS) disease activity is associated with blood-brain barrier (BBB) disruption, which is mediated by inflammatory cytokines released by CD4+ lymphocytes. To assess the effects of adenosine A2A receptors on BBB permeability in vitro and in vivo. METHODS A2A receptor expression was detected by immunostaining in experimental… CONTINUE READING