Adenosine A2A receptor activation stimulates collagen production in sclerodermic dermal fibroblasts either directly and through a cross-talk with the cannabinoid system

@article{Lazzerini2011AdenosineAR,
  title={Adenosine A2A receptor activation stimulates collagen production in sclerodermic dermal fibroblasts either directly and through a cross-talk with the cannabinoid system},
  author={Pietro Enea Lazzerini and Mariarita Natale and Elena Gianchecchi and Pier leopoldo Capecchi and Cinzia Montilli and Stefania Zimbone and Monica Castrichini and Epifania Balistreri and Gianluca Ricci and E. Kalai Selvi and Estrella Garcia-Gonzalez and Mauro Galeazzi and Franco Laghi-Pasini},
  journal={Journal of Molecular Medicine},
  year={2011},
  volume={90},
  pages={331-342}
}
Systemic sclerosis (SSc) is a connective tissue disease characterised by exaggerated collagen deposition in the skin and visceral organs. Adenosine A2A receptor stimulation (A2Ar) promotes dermal fibrosis, while the cannabinoid system modulates fibrogenesis in vitro and in animal models of SSc. Moreover, evidence in central nervous system suggests that A2A and cannabinoid (CB1) receptors may physically and functionally interact. On this basis, we investigated A2Ar expression and function in… CONTINUE READING
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