Adenosine A2A Receptor Blockade Modulates Glucocorticoid-Induced Morphological Alterations in Axons, But Not in Dendrites, of Hippocampal Neurons

@article{Pinheiro2018AdenosineAR,
  title={Adenosine A2A Receptor Blockade Modulates Glucocorticoid-Induced Morphological Alterations in Axons, But Not in Dendrites, of Hippocampal Neurons},
  author={Helena Pinheiro and Rita Gaspar and Filipa I. Baptista and Carlos A Fontes-Ribeiro and Ant{\'o}nio Francisco Ambr{\'o}sio and Catarina A. Gomes},
  journal={Frontiers in Pharmacology},
  year={2018},
  volume={9}
}
The exposure to supra-physiological levels of glucocorticoids in prenatal life can lead to a long-term impact in brain cytoarchitecture, increasing the susceptibility to neuropsychiatric disorders. Dexamethasone, an exogenous glucocorticoid widely used in pregnant women in risk of preterm delivery, is associated with higher rates of neuropsychiatric conditions throughout life of the descendants. In animal models, prenatal dexamethasone exposure leads to anxious-like behavior and increased… 
3 Citations

Figures from this paper

Adenosine A2A receptors blockade attenuates dexamethasone-induced alterations in cultured astrocytes.
TLDR
Findings suggest that alterations in astrocytes function, which might contribute to abnormal glucocorticoid brain signalling, are controlled by A2AR, and reinforce the relevance of A2 AR as a potential therapeutic target to manage mood disorders.
Adenosine A3 Receptor Mediates ERK1/2- and JNK-Dependent TNF-α Production in Toxoplasma gondii-Infected HTR8/SVneo Human Extravillous Trophoblast Cells
TLDR
Results indicate that A3AR-mediated activation of ERK1/2 and JNK positively regulates TNF-α secretion in T. gondii-infected HTR8/SVneo cells.

References

SHOWING 1-10 OF 43 REFERENCES
Adenosine A2A receptor blockade reverts hippocampal stress-induced deficits and restores corticosterone circadian oscillation
TLDR
It is shown that the dysfunction of the HPA-axis as well as the long-lasting synaptic and behavioral effects of MS can be reverted by targeting adenosine A2A receptors, providing a novel evidence for the use of adenosines A 2A receptor antagonists as potential therapy against psychopathologies.
Adenosine A2A receptor regulation of microglia morphological remodeling-gender bias in physiology and in a model of chronic anxiety
TLDR
It is reported that prenatal exposure to dexamethasone is associated with a gender-specific remodeling of microglial cell processes in the prefrontal cortex: males show a hyper-ramification and increased length whereas females exhibit a decrease in the number and in the length ofmicroglia processes.
The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function
TLDR
It is shown that inducing A2AR overexpression in an aging-like profile is sufficient to trigger HPA-axis dysfunction, namely loss of plasmatic corticosterone circadian oscillation, and promotes reduction of GR hippocampal levels, the first demonstration that A2 AR is a major regulator of GR function and that this functional interconnection may be a trigger to age-related memory deficits.
The bed nucleus of stria terminalis and the amygdala as targets of antenatal glucocorticoids: implications for fear and anxiety responses
TLDR
The results show that in utero DEX exposure can modulate anxiety and fear behavior in parallel with significant morphological, neurochemical and molecular changes; importantly, GCs seem to differentially affect distinct brain regions involved in this type of behaviors.
Programming effects of antenatal dexamethasone in the developing mesolimbic pathways
TLDR
Observances in this study identify glucocorticoid‐sensitive structures and neurochemical targets within the developing “reward pathway,” paving way for future studies designed to understand how early life events can predispose individuals for developing drug dependence in adolescent and adult life.
Prolonged corticosterone exposure induces dendritic spine remodeling and attrition in the rat medial prefrontal cortex
TLDR
This study examines the capacity of sustained increases in circulating corticosterone (B) alone to alter dendritic spine morphology and density in the medial prefrontal cortex and suggests that prolonged disruptions in adrenocortical functioning may be sufficient to induce enduring regressive structural and functional alterations in the mPFC.
Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress
TLDR
It is shown that caffeine prevents the maladaptive changes caused by CUS in a manner mimicked by the selective blockade of adenosine A2A receptors (A2AR), suggesting A2AR as candidate targets to alleviate the consequences of chronic stress on brain function.
Antenatal Glucocorticoid Treatment Affects Hippocampal Development in Mice
TLDR
Results show that dexamethasone treatment reduced body weight and hippocampal volume transiently during development, but these effects were no longer detected at adulthood, which may have important implications for hippocampal network function.
...
1
2
3
4
5
...