Adenosine A2A Agonists: A Potential New Type of Atypical Antipsychotic

  title={Adenosine A2A Agonists: A Potential New Type of Atypical Antipsychotic},
  author={Roberto Rimondini and Sergi Ferr{\'e} and Sven Ove {\"O}gren and Kjell Fuxe},
The systemic intraperitoneal (i.p.) administration of the adenosine A2A agonist CGS 21680 was found to dose-dependently antagonize spontaneous and amphetamine-induced (1 mg/kg i.p.) motor activity with similar ED50 values (about 0.2 mg/kg). The ratios between the ED50 values for induction of catalepsy and for antagonizing amphetamine-induced motor activity for CGS 21680, haloperidol, and clozapine were 12, 2, and > 30, respectively. Furthermore, CGS 21680 was comparably much stronger than… CONTINUE READING

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