Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine

@article{Huang2005AdenosineAB,
  title={Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine},
  author={Zhi-li Huang and Wei-min Qu and Naomi Eguchi and Nanako Imanaka and Michael A. Schwarzschild and Bertil B. Fredholm and Yoshihiro Urade and Osamu Hayaishi},
  journal={Nature Neuroscience},
  year={2005},
  volume={8},
  pages={858-859}
}
Caffeine, a component of tea, coffee and cola, induces wakefulness. It binds to adenosine A1 and A2A receptors as an antagonist, but the receptor subtype mediating caffeine-induced wakefulness remains unclear. Here we report that caffeine at 5, 10 and 15 mg kg−1 increased wakefulness in both wild-type mice and A1 receptor knockout mice, but not in A2A receptor knockout mice. Thus, caffeine-induced wakefulness depends on adenosine A2A receptors. 
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