Adenosine A1 receptors regulate the response of the mouse circadian clock to light.

@article{Sigworth2003AdenosineAR,
  title={Adenosine A1 receptors regulate the response of the mouse circadian clock to light.},
  author={Laura A Sigworth and Michael A. Rea},
  journal={Brain research},
  year={2003},
  volume={960 1-2},
  pages={246-51}
}
The purine nucleoside, adenosine, has been implicated in the regulation of circadian phase in the hamster. In the current report, we present pharmacological evidence supporting the involvement of adenosine A1 receptors in the regulation of the response of the circadian clock to light in mice. Systemic injection of the selective adenosine A1 receptor agonist, N(6)-cyclohexyladenosine (CHA; 0.3 mg/kg) resulted in a 49% reduction (P<0.05) in the magnitude of light-induced phase delays. The… CONTINUE READING

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