Adenosine A1 receptor agonists inhibit trigeminovascular nociceptive transmission.

@article{Goadsby2002AdenosineAR,
  title={Adenosine A1 receptor agonists inhibit trigeminovascular nociceptive transmission.},
  author={Peter J. Goadsby and Karen Lisa Hoskin and R J Storer and Lars Edvinsson and Helen E. Connor},
  journal={Brain : a journal of neurology},
  year={2002},
  volume={125 Pt 6},
  pages={
          1392-401
        }
}
There is a considerable literature to suggest that adenosine A1 receptor agonists may have anti-nociceptive effects, and we sought to explore the role of adenosine A1 receptors in a model of trigeminovascular nociceptive transmission. Cats were anaesthetized (alpha-chloralose 60 mg/kg, intraperitoneally), and prepared for physiological monitoring. The superior sagittal sinus (SSS) was stimulated electrically, and linked units were recorded in the trigeminocervical complex. Post-stimulus… Expand
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