Adenosine A1 and A2a receptors modulate insulinemia, glycemia, and lactatemia in fetal sheep.

@article{Maeda2009AdenosineAA,
  title={Adenosine A1 and A2a receptors modulate insulinemia, glycemia, and lactatemia in fetal sheep.},
  author={Takatsugu Maeda and Brian J. Koos},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2009},
  volume={296 3},
  pages={R693-701}
}
Adenosine A(1) and A(2A) receptor subtypes modulate metabolism in adult mammals. This study was designed to determine the role of these receptors in regulating plasma levels of insulin, glucose, and lactate in 20 chronically catheterized fetal sheep (>0.8 term). In normoxic fetuses (Pa(O(2)) approximately 24 Torr), systemic blockade of A(1) receptors with DPCPX (n = 6) increased plasma concentrations of insulin, glucose, and lactate, but antagonism of A(2A) receptors with ZM-241385 (n = 5) had… CONTINUE READING
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The effect of mild hypoxemia maintained for twenty-four hours on maternal R700 ADENOSINE MODULATES FETAL INSULIN, GLUCOSE, AND LACTATE AJP-Regul

  • ME Towell, J Figueroa, S Markowitz, B Elias, P. Nathanielsz
  • Integr Comp Physiol
  • 2009
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