Adenosine A1 and A2A receptor cross-talk during ageing in the rat myocardium.

@article{Arosio2003AdenosineAA,
  title={Adenosine A1 and A2A receptor cross-talk during ageing in the rat myocardium.},
  author={Beatrice Arosio and Stefano Perlini and Carmen Calabresi and Rossana Tozzi and Giuseppina Palladini and Adriano Ferrari and Carlo Vergani and Giorgio Annoni},
  journal={Experimental gerontology},
  year={2003},
  volume={38 8},
  pages={855-61}
}
Adenosine (Ado), a naturally occurring autacoid, exerts cardioprotective effects against myocardial ischemia and reperfusion injury, through activation of its receptors type 1 (A1) and 2A (A2A). Since ageing involves a complex change in these effects, we evaluated A1 and A2A gene expression in left (LV) and right ventricle (RV) from 2-, 5-, 12-, and 21-month-old Sprague-Dawley rats. LV end-diastolic (EDD) and end-systolic (ESD) internal dimensions (mm) and LV fractional shortening (FS, %) were… CONTINUE READING