Adenosine A1 and A2 receptors of the substantia gelatinosa are located predominantly on intrinsic neurons: an autoradiography study.

@article{Choca1988AdenosineAA,
  title={Adenosine A1 and A2 receptors of the substantia gelatinosa are located predominantly on intrinsic neurons: an autoradiography study.},
  author={J I Choca and Richard D. Green and Herbert K Proudfit},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1988},
  volume={247 2},
  pages={757-64}
}
Tissue autoradiography was used to examine the distribution of A1 and A2 adenosine receptors in the rat spinal cord. The distribution of binding sites for the A1 selective agonist, N6-[3H]-[(R)-1-methyl-2-phenylethyl]adenosine (R-[3H]PIA), was similar to the distribution of binding sites for [3H]-5'-N-ethylcarboxamide adenosine [( 3H]NECA), an agonist that binds to A1 and A2 receptors with nearly equal affinities. Binding site densities were highest in the substantia gelatinosa, followed by… CONTINUE READING