Adenosine A1 Receptor-mediated Modulation of Dopamine D1 Receptors in Stably Cotransfected Fibroblast Cells*

  title={Adenosine A1 Receptor-mediated Modulation of Dopamine D1 Receptors in Stably Cotransfected Fibroblast Cells*},
  author={S. Ferr{\'e} and M. Torvinen and K. Antoniou and E. Irenius and O. Civelli and E. Arenas and B. Fredholm and K. Fuxe},
  journal={The Journal of Biological Chemistry},
  pages={4718 - 4724}
  • S. Ferré, M. Torvinen, +5 authors K. Fuxe
  • Published 1998
  • Chemistry, Medicine
  • The Journal of Biological Chemistry
  • The antagonistic interactions between adenosine A1 and dopamine D1 receptors were studied in a mouse Ltk− cell line stably cotransfected with human adenosine A1 receptor and dopamine D1 receptor cDNAs. In membrane preparations, both the adenosine A1receptor agonist N 6-cyclopentyladenosine and the GTP analogue guanyl-5′-yl imidodiphospate induced a decrease in the proportion of dopamine D1 receptors in a high affinity state. In the cotransfected cells, the adenosine A1 agonist induced a… CONTINUE READING
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