Adenosine A Neuron-Glial Transmitter Promoting Myelination in the CNS in Response to Action Potentials

@article{Stevens2002AdenosineAN,
  title={Adenosine A Neuron-Glial Transmitter Promoting Myelination in the CNS in Response to Action Potentials},
  author={Beth Stevens and Stefania Porta and Laurel L. Haak and Vittorio Gallo and R I Fields},
  journal={Neuron},
  year={2002},
  volume={36},
  pages={855-868}
}
Neuronal activity influences myelination of the brain, but the molecular mechanisms involved are largely unknown. Here, we report that oligodendrocyte progenitor cells (OPCs) express functional adenosine receptors, which are activated in response to action potential firing. Adenosine acts as a potent neuron-glial transmitter to inhibit OPC proliferation… CONTINUE READING