Adenosine A 2A receptor deficiency reduces striatal glutamate outflow and attenuates brain injury induced by transient focal cerebral ischemia in mice.

@article{Gui2009AdenosineA2,
  title={Adenosine A 2A receptor deficiency reduces striatal glutamate outflow and attenuates brain injury induced by transient focal cerebral ischemia in mice.},
  author={Li Gui and W. Duan and Hong Tian and Chuanming Li and Jie Zhu and Jiang-fan Chen and Jian Zheng},
  journal={Brain research},
  year={2009},
  volume={1297},
  pages={185-93}
}
Recent studies have demonstrated that adenosine A(2A) receptor (A(2A)R) inactivation protects against brain injury caused by cerebral ischemia in various animal models. However, the underlying mechanisms remain to be fully elucidated. We examined the effect A(2A)R genetic inactivation on extracellular glutamate in the striatum and its relationship to the… CONTINUE READING