Adenosine A 2 B Receptors Behave as an Alternative Anchoring Protein for Cell Surface Adenosine Deaminase in Lymphocytes and Cultured Cells

@inproceedings{Herrera2000AdenosineA2,
  title={Adenosine A 2 B Receptors Behave as an Alternative Anchoring Protein for Cell Surface Adenosine Deaminase in Lymphocytes and Cultured Cells},
  author={Carolina Herrera and Vicent Casad{\'o} and Francisco Ciruela and Peter Schofield and Josefa Mallol and Carme Llu{\'i}s and Renato Franco},
  year={2000}
}
Adenosine deaminase (ADA) is an enzyme of the purine metabolism that has been largely considered to be cytosolic. Recently, it has been demonstrated that the enzyme appears on the surface of lymphocytes where it interacts with the T-cell activation antigen CD26. ADA also appears on the surface of nonlymphoid cells anchored to adenosine A1 receptors. Here it is demonstrated that cell surface ADA in ADA/CD26 T lymphocytes anchors to adenosine receptors of the A2B subtype (A2BR). An interaction… CONTINUE READING

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