Corpus ID: 39053615

Adenosine A 2 A Receptor Occupancy Stimulates Collagen Expression by Hepatic Stellate Cells via Pathways Involving Protein Kinase A , Src , and Extracellular Signal-Regulated Kinases 1 / 2 Signaling Cascade or p 38 Mitogen-Activated Protein Kinase Signaling Pathway

@inproceedings{Che2007AdenosineA2,
  title={Adenosine A 2 A Receptor Occupancy Stimulates Collagen Expression by Hepatic Stellate Cells via Pathways Involving Protein Kinase A , Src , and Extracellular Signal-Regulated Kinases 1 / 2 Signaling Cascade or p 38 Mitogen-Activated Protein Kinase Signaling Pathway},
  author={Jiantu Che and Edwin S. L. Chan and Bruce N. Cronstein},
  year={2007}
}
Prior studies indicate that adenosine and the adenosine A2A receptor play a role in hepatic fibrosis by a mechanism that has been proposed to involve direct stimulation of hepatic stellate cells (HSCs). The objective of this study was to determine whether primary hepatic stellate cells produce collagen in response to adenosine (via activation of adenosine A2A receptors) and to further determine the signaling mechanisms involved in adenosine A2A receptor-mediated promotion of collagen production… Expand

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