Adenosine A(3) receptor-mediated potentiation of mucociliary transport and epithelial ciliary motility.

@article{Taira2002AdenosineAR,
  title={Adenosine A(3) receptor-mediated potentiation of mucociliary transport and epithelial ciliary motility.},
  author={Manako Taira and Jun Tamaoki and Kazuyuki Nishimura and Junko Nakata and Mitsuko Kondo and Hisashi Takemura and Atsushi Nagai},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2002},
  volume={282 3},
  pages={
          L556-62
        }
}
  • M. Taira, J. Tamaoki, +4 authors A. Nagai
  • Published 1 March 2002
  • Biology, Medicine
  • American journal of physiology. Lung cellular and molecular physiology
To examine the effect of adenosine A(3) receptor stimulation on airway mucociliary clearance, we measured transport of Evans blue dye in rabbit trachea in vivo and ciliary motility of epithelium by the photoelectric method in vitro. Mucociliary transport was enhanced dose dependently by the selective A(3) agonist N(6)-(3-iodobenzyl)-5'-N-methylcarbamoyladenosine (IB-MECA) and to a lesser extent by the less-selective N(6)-2-(4-amino-3-iodophenyl)ethyladenosine, whereas the A(1) agonist N… 
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TLDR
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TLDR
The enzymatic properties of NPPs are reviewed and current evidence that links their nucleotide-hydrolyzing capability to epithelial and neural functions, the immune response and cell motility is analyzed.
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