Adenosine A(3) receptor activation protects the myocardium from reperfusion/reoxygenation injury.

@article{Maddock2002AdenosineAR,
  title={Adenosine A(3) receptor activation protects the myocardium from reperfusion/reoxygenation injury.},
  author={Helen L. Maddock and Mihaela M. Mocanu and Derek M Yellon},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2002},
  volume={283 4},
  pages={H1307-13}
}
Ischemia-reperfusion induces both necrotic and apoptotic cell death. The ability of adenosine to attenuate reperfusion-induced injury (RI) and the role played by adenosine receptors are unclear. We therefore studied the role of the A(3) receptor (A(3)R) in ameliorating RI using the specific A(3)R agonist 1-[2-chloro-6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-1-deoxi-N-methyl-b-D-ribofuranuronamide (2-Cl-IB-MECA). Isolated rat hearts and cardiomyocytes were subjected to ischemia or simulated… CONTINUE READING