Adenosine A(2) receptors inhibit morphine self-administration in rats.

  title={Adenosine A(2) receptors inhibit morphine self-administration in rats.},
  author={Hedayat Sahraei and Fereshteh Motamedi and Ali Khoshbaten and Mohammad Reza Zarrindast},
  journal={European journal of pharmacology},
  volume={383 2},
In the present study, the effect of adenosine receptor agonists and antagonists on morphine self-administration was investigated. Intravenous administration of morphine (0.3-3 mg/kg/injection) induced dose-dependent self-administration. The adenosine receptor antagonists, theophylline (2.5, 5, 10 mg/kg) and 3, 7-Dimethyl-1-propargylxanthine (DMPX; 0.25, 0.5, 1 mg/kg), when injected 1 h before the start of the test, reduced the number of self-administered morphine infusions. The adenosine… CONTINUE READING


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