Adenosine; a physiologic modulator of superoxide anion generation by human neutrophils. Adenosine acts via an A2 receptor on human neutrophils.

@article{Cronstein1985AdenosineAP,
  title={Adenosine; a physiologic modulator of superoxide anion generation by human neutrophils. Adenosine acts via an A2 receptor on human neutrophils.},
  author={Bruce Cronstein and Elliot D. Rosenstein and S B Kramer and Gerald Weissmann and Rochelle Hirschhorn},
  journal={Journal of immunology},
  year={1985},
  volume={135 2},
  pages={1366-71}
}
Adenosine specifically inhibits superoxide anion generation by N-formyl-methionyl-leucyl-phenylalanine-stimulated neutrophils without affecting either degranulation or "aggregation." We present data that also supports the hypothesis that adenosine engages a specific cell surface receptor to mediate inhibition of stimulated neutrophils. Theophylline (10 and 100 mu M), a competitive antagonist at adenosine receptors, reversed the effects of adenosine (0.1 mu M) on superoxide anion generation by… CONTINUE READING
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