Adenosine: a mediator of interleukin-1beta-induced hippocampal synaptic inhibition.

@article{Luk1999AdenosineAM,
  title={Adenosine: a mediator of interleukin-1beta-induced hippocampal synaptic inhibition.},
  author={W. P. Luk and Yu Zhang and T. D. White and F A Lue and Chun-Fu Wu and Charles Guobing Jiang and Ling Ling Zhang and Harvey Moldofsky},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1999},
  volume={19 11},
  pages={
          4238-44
        }
}
Interleukin-1 (IL-1) is a pleotrophic cytokine implicated in a variety of central activities, including fever, sleep, ischemic injury, and neuromodulatory responses, such as neuroimmune, and neuroendocrine interactions. Although accumulating evidence is available regarding the expression pattern of this cytokine, its receptors in the CNS, and its mechanistic profile under pathological levels, it is unclear whether this substance modulates central neurons under physiological concentrations… CONTINUE READING
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