Adenophostin A and ribophostin, but not inositol 1,4,5-trisphosphate or manno-adenophostin, activate the Ca2+ release-activated Ca2+ current, I(CRAC), in weak intracellular Ca2+ buffer.

@article{Parekh2002AdenophostinAA,
  title={Adenophostin A and ribophostin, but not inositol 1,4,5-trisphosphate or manno-adenophostin, activate the Ca2+ release-activated Ca2+ current, I(CRAC), in weak intracellular Ca2+ buffer.},
  author={A. Parekh and A. Riley and B. L. Potter},
  journal={The Biochemical journal},
  year={2002},
  volume={361 Pt 1},
  pages={
          133-41
        }
}
  • A. Parekh, A. Riley, B. L. Potter
  • Published 2002
  • Chemistry, Medicine
  • The Biochemical journal
  • Under physiological conditions of weak intracellular Ca(2+) buffering (0.1 mM EGTA), the second messenger Ins(1,4,5)P(3) often fails to activate any detectable store-operated Ca(2+) current. However, it has been reported that the fungal metabolite adenophostin A [which has a severalfold higher affinity than Ins(1,4,5)P(3) for Ins(1,4,5)P(3) receptors] consistently activates the current under similar conditions. Here, whole-cell patch clamp experiments have been performed to examine how… CONTINUE READING
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