Adenomatous polyposis coli localization is both cell type and cell context dependent.

@article{Langford2006AdenomatousPC,
  title={Adenomatous polyposis coli localization is both cell type and cell context dependent.},
  author={Kelly J Langford and Tae Ho Lee and Jon M. Askham and Ewan E. Morrison},
  journal={Cell motility and the cytoskeleton},
  year={2006},
  volume={63 8},
  pages={
          483-92
        }
}
The adenomatous polyposis coli (APC) tumor suppressor protein is mutated in most colorectal carcinomas. In addition to its role in WNT signaling it is proposed to be involved in both cell migration and mitosis. Although a variety of studies have shown an APC localization along lateral membranes of adjacent epithelial cells the existence of a cortical APC localization in mammalian cells remains controversial. To address this we have used matched rat epithelial (NRK-52E) and fibroblast (NRK-49F… CONTINUE READING

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