Adenomatous polyposis coli is present near the minimal level required for accurate graded responses to the Wingless morphogen.

@article{Benchabane2008AdenomatousPC,
  title={Adenomatous polyposis coli is present near the minimal level required for accurate graded responses to the Wingless morphogen.},
  author={Hassina Benchabane and Edward G. Hughes and Carter M. Takacs and Jason R. Baird and Yashi Ahmed},
  journal={Development},
  year={2008},
  volume={135 5},
  pages={963-71}
}
The mechanisms by which the Wingless (Wg) morphogen modulates the activity of the transcriptional activator Armadillo (Arm) to elicit precise, concentration-dependent cellular responses remain uncertain. Arm is targeted for proteolysis by the Axin/Adenomatous polyposis coli (Apc1 and Apc2)/Zeste-white 3 destruction complex, and Wg-dependent inactivation of destruction complex activity is crucial to trigger Arm signaling. In the prevailing model for Wg transduction, only Axin levels limit… CONTINUE READING

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