Adenomatous polyposis coli I1307K mutation in Jewish patients with different ethnicity: prevalence and phenotype.

@article{Drucker2000AdenomatousPC,
  title={Adenomatous polyposis coli I1307K mutation in Jewish patients with different ethnicity: prevalence and phenotype.},
  author={Liat Drucker and Ofer Shpilberg and Antje B. Neumann and Jeremiah Shapira and Rodica Stackievicz and Yoram Beyth and Shy Yarkoni},
  journal={Cancer},
  year={2000},
  volume={88 4},
  pages={755-60}
}
BACKGROUND A new mutation, I1307K, recently was reported in the adenomatous polyposis coli (APC) gene. This mutation was found to be predominant in Ashkenazi Jews, creating a hypermutable area and predisposing the development of carcinoma. The objective of the current study was to estimate the prevalence of this mutation in several of the ethnic groups that comprise the Israeli population and to elucidate the clinical features of the mutation carriers with colorectal carcinoma (CRC). METHODS… CONTINUE READING
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