Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene

@article{Aoki2007AdenomatousPC,
  title={Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene},
  author={K. Aoki and M. Taketo},
  journal={Journal of Cell Science},
  year={2007},
  volume={120},
  pages={3327 - 3335}
}
The adenomatous polyposis coli (APC) gene is a key tumor suppressor gene. Mutations in the gene have been found not only in most colon cancers but also in some other cancers, such as those of the liver. The APC gene product is a 312 kDa protein that has multiple domains, through which it binds to various proteins, including β-catenin, axin, CtBP, Asefs, IQGAP1, EB1 and microtubules. Studies using mutant mice and cultured cells have demonstrated that APC suppresses canonical Wnt signalling… Expand
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