Adenomatous polyposis coli/beta-catenin interaction and downstream targets: altered gene expression in gastrointestinal tumors.

@article{Clements2003AdenomatousPC,
  title={Adenomatous polyposis coli/beta-catenin interaction and downstream targets: altered gene expression in gastrointestinal tumors.},
  author={Wilson M. Clements and Andrew M. Lowy and Joanna Groden},
  journal={Clinical colorectal cancer},
  year={2003},
  volume={3 2},
  pages={
          113-20
        }
}
Gastrointestinal cancer affects 250,000 Americans a year with nearly half of those cases being colorectal cancer. The Wnt pathway is activated in most spontaneous and familial colorectal cancers and has been implicated in tumor formation at other sites in the gastrointestinal tract. In human tumors, the Wnt pathway is most often altered by mutations affecting certain components of this signal transduction cascade-the adenomatous polyposis coli (APC) tumor suppressor gene or the ss-catenin gene… CONTINUE READING

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