Adenomatous Polyposis Coli (APC) Protein Moves along Microtubules and Concentrates at Their Growing Ends in Epithelial Cells

@article{MimoriKiyosue2000AdenomatousPC,
  title={Adenomatous Polyposis Coli (APC) Protein Moves along Microtubules and Concentrates at Their Growing Ends in Epithelial Cells},
  author={Yuko Mimori-Kiyosue and Nobuyuki Shiina and Shoichiro Tsukita},
  journal={The Journal of Cell Biology},
  year={2000},
  volume={148},
  pages={505 - 518}
}
Adenomatous polyposis coli (APC) tumor suppressor protein has been shown to be localized near the distal ends of microtubules (MTs) at the edges of migrating cells. We expressed green fluorescent protein (GFP)-fusion proteins with full-length and deletion mutants of Xenopus APC in Xenopus epithelial cells, and observed their dynamic behavior in live cells. During cell spreading and wound healing, GFP-tagged full-length APC was concentrated as granules at the tip regions of cellular extensions… CONTINUE READING
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