Adenoid cystic carcinoma of the lacrimal gland: MYB gene activation, genomic imbalances, and clinical characteristics.

@article{Holstein2013AdenoidCC,
  title={Adenoid cystic carcinoma of the lacrimal gland: MYB gene activation, genomic imbalances, and clinical characteristics.},
  author={Sarah Lin{\'e}a von Holstein and Andr{\'e} Fehr and Marta Persson and Marianne Hamilton Therkildsen and Jan Ulrik Prause and Steffen Heegaard and G{\"o}ran Stenman},
  journal={Ophthalmology},
  year={2013},
  volume={120 10},
  pages={2130-8}
}
PURPOSE To investigate genetic alterations in lacrimal gland adenoid cystic carcinomas (ACCs) with emphasis on the MYB-NFIB fusion oncogene and its downstream targets, MYB rearrangements, and copy number alterations in relation to clinical data and survival. DESIGN Experimental study. PARTICIPANTS AND CONTROLS Fourteen patients with primary lacrimal gland ACC were included. As a control, we also studied the expression of MYB-NFIB in 19 non-ACC lacrimal gland tumors. METHODS The expression… CONTINUE READING